General Information

  • ID:  hor004886
  • Uniprot ID:  P42998
  • Protein name:  Annetocin
  • Gene name:  NA
  • Organism:  Eisenia fetida (Red wiggler worm)
  • Family:  Vasopressin/oxytocin family
  • Source:  animal
  • Expression:  NA
  • Disease:  NA
  • Comments:  NA
  • Taxonomy:  Eisenia (genus), Lumbricinae (subfamily), Lumbricidae (family), Lumbricina (suborder), Crassiclitellata (order), Oligochaeta (subclass), Clitellata (class), Annelida (phylum), Lophotrochozoa, Spiralia, Protostomia, Bilateria, Eumetazoa, Metazoa (kingdom), Opisthokonta, Eukaryota (superkingdom), cellular organisms
  • GO MF:  GO:0005179 hormone activity; GO:0005185 neurohypophyseal hormone activity
  • GO BP:  GO:0007165 signal transduction
  • GO CC:  GO:0005576 extracellular region

Sequence Information

  • Sequence:  CFVRNCPTG
  • Length:  9
  • Propeptide:  CFVRNCPTG
  • Signal peptide:  NA
  • Modification:  T9 Glycine amide
  • Glycosylation:  NA
  • Mutagenesis:  NA

Activity

  • Function:  Potentiates spontaneous contractions of the gut and also pulsatory contractions and bladder-shaking movement of the nephridia. May be involved in osmoregulation of the animal through nephridial function.
  • Mechanism:  NA
  • Cross BBB:  NO
  • Target:  NA
  • Target Unid:  NA
  • IC50: NA
  • EC50: NA
  • ED50: NA
  • kd: NA
  • Half life: NA

Structure

  • Disulfide bond:  1-6
  • Structure ID:  NA

  • Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)
    •    hor004886_AF2.pdbhor004886_ESM.pdb

Physical Information

Mass: 113904 Formula: C41H65N13O12S2
Absent amino acids: ADEHIKLMQSWY Common amino acids: C
pI: 8.23 Basic residues: 1
Polar residues: 5 Hydrophobic residues: 2
Hydrophobicity: 14.44 Boman Index: -1361
Half-Life: 1.2 hour Half-Life Yeast: >20 hour
Half-Life E.Coli: >10 hour Aliphatic Index 32.22
Instability Index: 3136.67 Extinction Coefficient cystines: 125
Absorbance 280nm: 15.63

Literature

  • PubMed ID:  8292046
  • Title:  Annetocin: an oxytocin-related peptide isolated from the earthworm, Eisenia foetida.